Rare Bleeding Disorders

Factor XIII deficiency

Factor XIII deficiency is very rare, occurring in about 1 of every 3 million people. It is equally likely to affect men and women.1

Factor XIII deficiency is often severe. Women with the disorder have an increased risk of problems during pregnancy, including miscarriage.1

Common symptoms include1:

  • Nosebleeds
  • Easy bruising
  • Heavy menstrual bleeding
  • Joint bleeding
  • Persistent bleeding in babies at the site of the umbilical cord or during circumcision
  • Poor wound healing and scar formation


The preferred treatment for factor XIII deficiency is factor concentrate. Birth control pills and antifibrinolytics are sometimes prescribed to control heavy periods.


  1. What Are Rare Clotting Factor Deficiencies? Montreal, QC: World Federation of Hemophilia; 2009.