Rare Bleeding Disorders

Factor VII Deficiency

Approximately 1 in 500,000 people have factor VII deficiency. This condition is inherited in an autosomal recessive fashion, which means it is equally likely to affect men and women.1

Factor VII deficiency is usually severe. When factor VII levels are extremely low, patients can experience1:

  • Spontaneous nosebleeds
  • Head bleeds among newborns
  • Easy bruising
  • Prolonged or heavy periods

Less commonly, people with factor VII deficiency may have bleeding in the stomach and intestines.


Factor VII concentrate or recombinant factor VIIa can be used to treat patients with congenital factor VII deficiency.2 Your hematologist will give you all the information you need to effectively manage your condition.


  1. What Are Rare Clotting Factor Deficiencies? Montreal, QC: World Federation of Hemophilia; 2009.
  2. MASAC recommendations concerning products licensed for the treatment of hemophilia and other bleeding disorders (revised September 2014.) MASAC Document 230. National Hemophilia Foundation website. http://www.hemophilia.org/sites/default/files/document/files/230Text2014-09.pdf. Accessed December 18, 2014.