Hemophilia B Symptoms

The symptoms of hemophilia B depend on how severe the condition is.

People with mild hemophilia B may only experience symptoms in certain instances, such as a dental procedure, accident, or surgery. In these cases, it is important to let your dentist and other healthcare professional know about your condition ahead of time so they can take the necessary precautions.

Other symptoms of hemophilia B include1:

  • Bleeding into joints with associated pain and swelling
  • Blood in urine or stool (bowel movements)
  • Bruising
  • Gastrointestinal tract and urinary tract hemorrhage
  • Nosebleeds
  • Prolonged bleeding from cuts, tooth extraction, and surgery

People with moderate to severe hemophilia B may also experience occasional bleeding episodes, without obvious cause, often into the joints and muscles. These are called spontaneous bleeding episodes and are more frequent in patients with severe hemophilia B.2

For parents: Noticing signs in your child

Parents of a male child with hemophilia B often discover the condition when he has a bleeding episode following circumcision.3 Otherwise, the signs of hemophilia B aren’t usually noticeable until the child is a toddler, when injuries are more common.

Signs that your toddler could have hemophilia include4:

  • Prolonged nosebleeds
  • Large bruises (from bleeding into large muscles of the body)
  • Bleeding in the mouth when a child bites on his or her lips or tongue, or from cutting or losing a tooth

Another common type of bleed—although not always the most obvious—is a muscle or joint bleed.4

Bleeding in the brain may occur in hemophilia B patients after a bump on the head or a more serious injury. Symptoms include4:

  • Persistent, painful headaches
  • Neck pain or stiffness
  • Repeated vomiting
  • Changes in behavior
  • Sleepiness
  • Difficulty walking
  • Sudden weakness or clumsiness of the arms or legs
  • Double vision
  • Seizures or convulsions

For more information

Caring for Children


  1. Hemophilia B. PubMed Health website. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001566. Updated February 8, 2012. Accessed October 22, 2014.
  2. Hemophilia B. National Hemophilia Foundation website. https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Hemophilia-B. Accessed October 21, 2014.
  3. Kulkarni R, Soucie JM, Lusher J, et al; Haemophilia Treatment Center Network Investigators. Sites of initial bleeding episodes, mode of delivery and age of diagnosis in babies with haemophilia diagnosed before the age of 2 years: a report from The Centers for Disease Control and Prevention’s (CDC) Universal Data Collection (UDC) project. Haemophilia. 2009;15(6):1281-90.
  4. What are the signs and symptoms of hemophilia? National Institutes of Health; National Heart, Lung, and Blood Institute website. http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/signs.html. Updated July 31, 2013. Accessed October 22, 2014.